Indira

Raman

• 2014 Spring - Tutorial in Biology - BIOL_SCI
• 2014 Winter - ISP Neurobiology - BIOL_SCI
• 2014 Winter - Tutorial in Biology - BIOL_SCI

• Bant JS, Raman IM. (2010). Control of transient, resurgent, and persistent current by open-channel block by Na channel {beta}4 in cultured cerebellar granule neurons. Proc Natl Acad Sci U S A. Jun 21. [Full Text]
• Person AL, Raman IM. (2010). Deactivation of L-type Ca current by inhibition controls LTP at excitatory synapses in the cerebellar nuclei. Neuron. May 27;66(4):550-9. [Full Text]
• Aman TK, Raman IM. (2010). Inwardly permeating Na ions generate the voltage dependence of resurgent Na current in cerebellar Purkinje neurons. J Neurosci. Apr 21;30(16):5629-34. [Full Text]
• Zheng N, Raman IM. (2010). Synaptic inhibition, excitation, and plasticity in neurons of the cerebellar nuclei. Cerebellum. Mar;9(1):56-66. [Full Text] [Full Text]
• Benton MD, Raman IM. (2009). Stabilization of Ca current in Purkinje neurons during high-frequency firing by a balance of Ca-dependent facilitation and inactivation. Channels (Austin). Nov 13;3(6).
• Zheng N, Raman IM. (2009). Ca currents activated by spontaneous firing and synaptic disinhibition in neurons of the cerebellar nuclei. J Neurosci. Aug 5;29(31):9826-38. [Full Text]

Information in the nervous system is transmitted by electrical signals (action potentials) within neurons and by chemical signals between neurons. The research interests of this lab are in studying the biophysical properties of voltage- and ligand-gated ion channels intrinsic to neurons, as well as in understanding the physiological consequences of the different patterns of activity characteristic of specific neurons.

We are currently studying neurons of the cerebellum, a brain region that participates in controlling movements. Projects in the lab focus on the ionic mechanisms of high-frequency firing in Purkinje neurons, the transmission of synaptic signals from Purkinje to cerebellar nuclear cells, and the response of cerebellar nuclear cells to different patterns of synaptic input. These types of studies will be useful for the development of accurate computer models of neuronal activity, as well as for cellular-level interpretations of systems-level studies of cerebellar function.